Effect of Gender and Age on the Cardiac Enzyme (Creatinine Kinase, CKmm)
DOI:
https://doi.org/10.47540/ijcs.v3i1.1338Keywords:
Age, Cardiac Enzyme, Creatinine Kinase, GenderAbstract
Creatine kinase is expressed at high levels in muscle, where it plays a central role in energy metabolism. Amid to explore the effect of gender and age on baseline blood creatine kinase levels in a large group of adults. Material and Methods: The collected samples 382 from four labs in three Cities in the eastern region of Libya, where 36 samples were collected from the Al-Bara laboratory (83 samples from the Al-Rashid laboratory from the Derna City, 182 samples from the Al-Biruni laboratory in the Tobruk City and 81 samples from the Al-Razi laboratory from Benghazi. Result: The Creatinine Kinase (CK) Result for 382 samples was a high percentage of 215 (56.3 %) and the normal percentage of 167 (43.7 %), the Frequency and percentage of males 196(51.3%), and for females 186(48.7 %), the relationship between age group and the result of Creatinine Kinase (CK) that the highest result was in (51 – 55 years) followed by (41 – 45 years), (61 – 65 years) and > 80, the difference between male and female in the result of Creatinine Kinase (CK) that the number of the highest result was 110 in males, 105 in females, but there are not a huge difference between them, the difference between male and female in the result of Creatinine Kinase (CK) the Correlations between Creatinine Kinase (CK) Result and age, gender due to the p-value more than 0.000. Conclusion: Data analysis shows that age and sex do not affect the result of creatinine cardiac enzymes (CK).
References
Clifford, S. M., Bunker, A. M., Jacobsen, J. R., & Roberts, W. L. (2011). Age and gender specific pediatric reference intervals for aldolase, amylase, ceruloplasmin, creatine kinase, pancreatic amylase, prealbumin, and uric acid. Clinica Chimica Acta, 412(9–10), 788–790.
Efobi, H. A., & Bassey, I. E. (2021). Influence of Gender on Total Serum Creatine Kinase and Creatine Kinase-Mb Levels of Nigerian Hypertensives. Birat Journal of Health Sciences, 6(2), 1436–1439.
Eljamay, S. M., & Nuesry, M. S. (2024). Cardiac Enzymes (Creatinine Kinase, Troponin I) and Their Gender Relationship. المجلة الأفروآسيوية للبحث العلمي (AAJSR), 57–64. https://aajsr.com/index.php/aajsr/article/view/105
Fairweather, D., Beetler, D. J., Musigk, N., Heidecker, B., Lyle, M. A., Cooper, L. T., & Bruno, K. A. (2023). Sex and gender differences in myocarditis and dilated cardiomyopathy: An update. Frontiers in Cardiovascular Medicine, 10.
Gledhill, R. F., Van der Merwe, C. A., Greyling, M., & Van Niekerk, M. M. (1988). Race-gender differences in serum creatine kinase activity: A study among South Africans. Journal of Neurology, Neurosurgery, and Psychiatry, 51(2), 301–304.
Lygate, C. A., Medway, D. J., Ostrowski, P. J., Aksentijevic, D., Sebag-Montefiore, L., Hunyor, I., Zervou, S., Schneider, J. E., & Neubauer, S. (2012). Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age. Basic Research in Cardiology, 107(5), 276.
Mazhar, F., Tariq, S. R., & Bashir, F. (2011). Age- and Gender-Based Studies of Trace Metal Levels and Various Enzymes Associated with Myocardial Infarction. Biological Trace Element Research, 140(2), 139–150.
Neal, R. C., Ferdinand, K. C., Yčas, J., & Miller, E. (2009). Relationship of Ethnic Origin, Gender, and Age to Blood Creatine Kinase Levels. The American Journal of Medicine, 122(1), 73–78.
Oosthuyse, T., & Bosch, A. N. (2017). The Effect of Gender and Menstrual Phase on Serum Creatine Kinase Activity and Muscle Soreness Following Downhill Running. Antioxidants, 6(1), 16.
Singh, N., Aggarwal, J., Batra, J., & Srivastava, N. (2022). Gender-differences in the association between creatine kinase and lipid profile in diabetic patients. Journal of Pharmaceutical Negative Results, 13(7).
Somjen, D., Katzburg, S., Sharon, O., Knoll, E., Hendel, D., & Stern, N. (2011). Sex specific response of cultured human bone cells to ERα and ERβ specific agonists by modulation of cell proliferation and creatine kinase specific activity. The Journal of Steroid Biochemistry and Molecular Biology, 125(3–5), 226–230.
Wong, E. T., & Haywood, L. J. (1983). Heterogeneity of Serum Creatine Kinase Activity among Racial and Gender Groups of the Population. 79(5).